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Tn antigen
Tn antigen refers to the "oligosaccharide" (in fact monosaccharide) structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond, i.e. as an O-glycan. It is not usually found on healthy cell surfaces, but may be found on cancer cells.〔I. Brockhausen, H. Schachter, P. Stanley, Essentials of Glycobiology, 2nd edition. A. Varki, R. Cummings, J. Esko, Eds, Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 9, O-GalNAc Glycans〕 Addition of single monosaccharide residues creates disaccharide antigens: the Thomsen-Friedenreich antigen (TF antigen or T antigen) is formed by substitution with galactose (Gal(b1-3)GalNAc); the sialyl Tn antigen (STn antigen) is formed by substitution with sialic acid (Neu5Ac(a2-6)GalNAc. Further substitution gives the normal core structures and O-glycans found on healthy cell surfaces.
== References ==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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